Euphorbia leucodendron is found in subhumid, dry or subarid south-western bush areas of Madagascar, as well as the inselbergs and rock faces of the southern central high-plateau. Plants growing in the south-west don’t seem to be restricted by the nature of the soil whereas individuals from the high-plateau require well drained rock outcrops to grow, greatly limiting potential localities. This species is common throughout its range. The area is very rich in succulent plants, some of which are endemic to the region.
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